Purin-6-One Derivatives as Phosphodiesterase-2 Inhibitors
نویسندگان
چکیده
منابع مشابه
QSAR Analysis for Some 1, 2-Benzisothiazol-3-one Derivatives as Caspase-3 Inhibitors by Stepwise MLR Method
Caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. Hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. Caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (QSAR) using ste...
متن کاملQSAR Analysis for Some 1, 2-Benzisothiazol-3-one Derivatives as Caspase-3 Inhibitors by Stepwise MLR Method
Caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. Hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. Caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (QSAR) using ste...
متن کاملPhosphodiesterase Inhibitors as Immunomodulatory Drugs
Los niveles intracelulares de nucleótidos cíclicos (cAMP, cGMP) tienen un papel esencial en la regulación de múltiples funciones de las células inmunes. Las fosfodiesterasas (FDEs) son un grupo grande de enzimas que ejercen un papel muy importante en la regulación de los niveles intracelulares de nucleótidos cíclicos. La pentoxifilina es un inhibidor no específico de FDE que tiene diferentes ef...
متن کامل2-Chloro-N-ethyl-9-isopropyl-9H-purin-6-amine
In the title compound, C(10)H(14)ClN(5), the purine ring system is essentially planar, with an r.m.s. deviation from the least-squares plane defined by the nine constituent atoms of 0.0063 (11) Å. In the crystal, mol-ecules are linked by weak N-H⋯N and C-H⋯π inter-actions.
متن کامل9 - ( 4 - Methoxyquinazolin - 2 - yl ) - 9 H - purin - 6 - amine
A novel hybrid consisting of quinazoline and adenine moieties has been synthesized as a precursor of a potential biologically active target compound. The structure of 9-(4-methoxyquinazolin-2-yl)-9H-purin-6-amine (2) was characterized and confirmed using the following spectroscopic methods: LC-UV-MS, 1H-NMR, 13C-NMR and HSQC-NMR.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chemistry
سال: 2016
ISSN: 2090-9063,2090-9071
DOI: 10.1155/2016/6878353